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To gain a deeper understanding of the cellular mechanisms underlying WD, a reanalysis of the GSE1073236 dataset was conducted and validated by comparative analyses in a cell culture model of HepG2 and HepG2 ATP7B knockout (ATP7B-KO) cells, as well as in primary hepatocytes from WD patients and controls

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Important Epithalon Research Limitations The literature is concentrated within a small research network and relies heavily on preclinical models

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The most significant changes to body composition typically become apparent from months three to six and beyond